累積人生的智慧 [2009-03-31]

2009-03-30

 

「肯承認錯誤並虛心改進的人才能增長智慧。」

 

恭錄自 證嚴法師 所述的 [靜思語] 一書

 

 

2009-03-30

 

累積人生的智慧

 

「能夠不恥下問，可以虛心接受別人的批評，又能勇於承認自身的錯誤，並且願意針對問題之所在，主動進取地採取實際的行動，確確實實地著手去進行自我改革的人，自然就能夠與時俱進，不斷地累積出真正屬於自己的智慧。」

 

湯偉晉 （WeiJin Tang） 親手逐字地寫於 西元 2009-03-30

 

2009-03-31

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Keywords:
累積人生的智慧_[2009-03-31]

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URL of Google Sites used by WeiJin Tang at [WeiJin.Tang@gmail.com] [2009-03-27]

2009-03-27

URL of  Google Sites used by WeiJin Tang at [WeiJin.Tang@gmail.com]

http://sites.google.com/site/WeiJinTang/

善解科技 - 為這個世界打造一個更美好的未來[2009-02-23].PNG

2009-02-23

善解科技 - 為這個世界打造一個更美好的未來

SoftHuman Corporation - Build a better future for the whole world.

Drawing by [Douglas Tang (湯傑堯)][2009-03-12](IR88) (1_of_4)(for BlogSpot)(40PoO).jpg

March 13, 2009; 06:11:19 p.m. Taipei Time

Drawing by [Douglas Tang (湯傑堯)][2009-03-12](IR88) (1_of_4)(for BlogSpot)(40PoO).jpg

Drawing by [Douglas Tang (湯傑堯)]{Dolphin (海豚)}(IR92)[2004-08-04](50PoO).jpg

The major determinants (決定因素) of GSH synthesis are the availability of cysteine, and the activity of the rate-limiting enzyme, g-glutamylcysteine synthetase (GCS)[1999](IR90)

 

The major determinants (決定因素) of GSH synthesis are the availability of cysteine, and the activity of the rate-limiting enzyme, g-glutamylcysteine synthetase (GCS)[1999](IR90)

 

Regulation of hepatic glutathione synthesis: current concepts and controversies SHELLY C. LU

USC Liver Disease Research Center, the Division of Gastrointestinal (胃腸的) and Liver Diseases, Department of Medicine, University of Southern California School of Medicine, Los Angeles, California 90033, USA

 

ABSTRACT

 

Glutathione (GSH) is an important intracellular peptide with multiple functions ranging from antioxidant defense to modulation of cell proliferation. GSH is synthesized in the cytosol (【生物學】細胞溶質) of all mammalian (哺乳動物(的)) cells in a tightly regulated manner. The major determinants (決定因素) of GSH synthesis are the availability of cysteine, the sulfur amino acid precursor, and the activity of the rate-limiting enzyme, g-glutamylcysteine synthetase (GCS). In the liver, major factors that determine the availability of cysteine are diet, membrane transport activities of the three sulfur amino acids cysteine, cystine and methionine, and the conversion of methionine to cysteine via the trans-sulfuration pathway. Many conditions alter GSH level via changes in GCS activity and GCS gene expression. These include oxidative stress, activators of Phase II detoxifying enzymes, antioxidants, drug-resistant tumor cell lines, hormones, cell proliferation, and diabetes mellitus (糖尿病). Since the molecular cloning (複製) of GCS, much has been learned about the regulation of this enzyme. Both transcriptional and post-transcriptional mechanisms modulate the activity of this critical cellular enzyme.

 

Lu, S. C. Regulation of hepatic glutathione synthesis: current concepts and controversies. FASEB J. 13, 1169-1183 (1999)

 

Key Words:

g-glutamylcysteine synthetase , cysteine availability , detoxification , antioxidant