Glutathione (穀胱甘肽) metabolism in brain - Metabolic interaction between astrocytes (【生】星細胞) and neurons (神經細胞) in the defense against reactive oxygen species [2000](IR92)

Glutathione (穀胱甘肽) metabolism in brain - Metabolic interaction between astrocytes (【生】星細胞) and neurons (神經細胞) in the defense against reactive oxygen species [2000](IR92)

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(Memo Item created on September 1, 2009 01:18 PM)
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Glutathione (穀胱甘肽) metabolism in brain
Metabolic interaction between astrocytes (【生】星細胞) and neurons (神經細胞) in the defense against reactive oxygen species

http://www3.interscience.wiley.com/journal/119181433/abstract?CRETRY=1&SRETRY=0
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European Journal of Biochemistry
Volume 267 Issue 16, Pages 4912 - 4916
Published Online: 25 Dec 2001

Glutathione (穀胱甘肽) metabolism in brain
Metabolic interaction between astrocytes (【生】星細胞) and neurons (神經細胞) in the defense against reactive oxygen species

Ralf Dringen, Jan M. Gutterer and Johannes Hirrlinger
Physiologisch-chemisches Institut der Universität, Tübingen, Germany (德國)
Correspondence to R. Dringen, Physiologisch-chemisches Institut der Universität, Hoppe-Seyler-Strasse 4, D-72076 Tübingen, Germany (德國).
Fax: +49 7071 295360, Tel.: +49 7071 2973334 , E-mail: ralf.dringen@uni-tuebingen.de

Copyright FEBS, 2000

KEYWORDS
astrocytes (【生】星細胞) • brain • glutathione (穀胱甘肽) • neurodegeneration • neurons (神經細胞)

ABSTRACT
The cells of the adult human brain consume ≈ 20% of the oxygen utilized by the body although the brain comprises only 2% of the body weight. Reactive oxygen species, which are produced continuously during oxidative metabolism, are generated at high rates within the brain. Therefore, the defense against the toxic effects of reactive oxygen species is an essential task within the brain. An important component of the cellular detoxification of reactive oxygen species is the antioxidant glutathione (穀胱甘肽). The main focus of this short review is recent results on Glutathione (穀胱甘肽) metabolism of brain astrocytes (【生】星細胞) and neurons (神經細胞) in culture. These two types of cell prefer different extracellular precursors for glutathione (穀胱甘肽). glutathione (穀胱甘肽) is involved in the disposal of exogenous peroxides by astrocytes (【生】星細胞) and neurons (神經細胞). In coculture astrocytes (【生】星細胞) protect neurons (神經細胞) against the toxicity of reactive oxygen species. One mechanism of this interaction is the supply by astrocytes (【生】星細胞) of glutathione (穀胱甘肽) precursors to neurons (神經細胞).

(Received 5 January 2000, accepted 25 February 2000)

DIGITAL OBJECT IDENTIFIER (DOI)
10.1046/j.1432-1327.2000.01597.x About DOI

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